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  • Pharmaceuticals & Healthcare

    Whilst demanding particular skills and expertise, the pharmaceutical and healthcare sectors today face commercial challenges common to many organisations within the broader process industries.

    The concept of a recession-proofed sector is a dated perception, particularly when considering the high costs of product research, development, approval and general compliance.

    Costs at all levels are under scrutiny, including those for design, engineering and plant construction. It is increasingly recognised that present day levels of investment and inherent need for flexibility demand appropriately sized and ‘fit for purpose’ supply organisations, working in partnership.

    In such a difficult market place, combined with the need to sustain competitive advantage and accelerate new products to market, Capita PROjEN has the people and product mix to add value to its clients’ engineering functions.

    The consolidation and growth of Capita PROjEN’s pharmaceutical business is a reflection of this evolution. Capita PROjEN enjoy Alliance and Approved Supplier agreements going back as far as 17 years with leading blue chips companies such as Sanofi, GlaxoSmithKline and Smith & Nephew.

    Our engineering experience covers the full spectrum of requirements for this sector which includes a working knowledge of current Good Manufacturing Practise (cGMP). We have a track record for the concept development, design, construction, and commissioning of a multitude of process related equipment and systems including liquid and powder handling and storage, reactor control (including heat/cool options), isolation (eg glove box technology), filtration and drying.

    Capita PROjEN have further expertise in sterilisation, aseptic filling, tableting/coating/forming together with ‘Clean in place/Steam in place’ and purified water systems to ISPE guidelines.

    In recent years, Capita PROjEN have completed a number of both large and smaller projects in the following specialist market places:

    • Primary Pharmaceuticals and active ingredients
    • Secondary Pharmaceuticals
    • Biotechnology
    • Personal care
    • Nutrition
    • Related Infrastructure works
    • Laboratories, development rigs, pilot scale facilities and multi purpose plants.

    With specific experience in the following:

    • Lab scale and pilot plant development
    • Office/Laboratory/Cleanroom design (ISO 14644-1/2) and upgrade
    • Solids/powder handling, storage and processing
    • Liquid handling and processing
    • Liquid Fill – Capsules, vials, syringe bottles
    • Tableting
    • Purification
    • Lyophilisation (Freeze Drying)
    • Chromatography, including Reverse Phase, HPLC
    • Distillation (Batch & Continuous)
    • Conversion of batch to continuous manufacture
    • Clean water systems – including water for injection (WFI) + USP/BP purified water
    • Pressure/Vacuum filtration
    • Reactors (including heat/cool control and relief systems)
    • Contamination control and clean room specification / operation (flow logistics)
    • Sterile manufacture (including by microfiltration)
    • Spray Drying
    • Toxic / bioactive materials handling, control and containment
    • ATEX / DSEAR Directives
    • SHE, CDM, Hazop all with cGMP compliance
    • Building Services including; HVAC/Environmental control & fire protection
    • Process Validation
    • Refridgeration technology.